Multiregional tumor trees are not phylogenies

Our comment about misusing multiregional trees in cancer is out:

Alves JA, Prieto T, Posada D. 2017. Multiregional tumor trees are not phylogenies. TrendsĀ in Cancer: 0.1016/j.trecan.2017.06.004

Here we show that multiregional tumor trees built from bulk mutational profiles ignore intratumor heterogeneity and can lead to wrong conclusions. At the heart of this is the confusion between population trees vs. gene trees (i.e., multiregional tumor trees vs. clonal trees).

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