Multiregional tumor trees are not phylogenies

Our comment about misusing multiregional trees in cancer is out:

 
Alves JA, Prieto T, Posada D. 2017. Multiregional tumor trees are not phylogenies. TrendsĀ in Cancer: 0.1016/j.trecan.2017.06.004

 
https://t.co/HVb8dVpi6O

 
Here we show that multiregional tumor trees built from bulk mutational profiles ignore intratumor heterogeneity and can lead to wrong conclusions. At the heart of this is the confusion between population trees vs. gene trees (i.e., multiregional tumor trees vs. clonal trees).

This entry was posted in Publications, Research and tagged . Bookmark the permalink.