Author Archives: Miguel Arenas

Substitution Rates Predicted by Stability-Constrained Models of Protein Evolution Are Not Consistent with Empirical Data

Posted on March 3, 2018 by Miguel Arenas

Both stability-constrained and structure-constrained substitution models are required to realistically predict the effect of mutations during protein evolution. A great study with Ugo Bastolla’s lab just published in Molecular Biology and Evolution, https://academic.oup.com/mbe/article-abstract/35/3/743/4775142?redirectedFrom=fulltext

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Evaluating the Neolithic Expansion at Both Shores of the Mediterranean Sea

Posted on November 24, 2017 by Miguel Arenas

The Neolithic expansion at both shores of the Mediterranean Sea was not different after all. A nice study applying approximation Bayesian computation for model selection and parameters estimation. Just published in Molecular Biology and Evolution, https://academic.oup.com/mbe/article/34/12/3232/4237582  

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ProtASR: An Evolutionary Framework for Ancestral Protein Reconstruction with Selection on Folding Stability

Posted on October 14, 2017 by Miguel Arenas

A new evolutionary framework for ancestral protein reconstruction accounting for structural constraints, just published in Systematic Biology https://academic.oup.com/sysbio/article-abstract/66/6/1054/2840014/ProtASR-An-Evolutionary-Framework-for-Ancestral?redirectedFrom=fulltext

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Forensic genetics and genomics: Much more than just a human affair

Posted on September 22, 2017 by Miguel Arenas

A comprehensive review on the diverse disciplines of nonhuman forensic genetics, just published in PLoS Genetics. Indeed, it is a fantastic collaboration with the lab of Antonio Amorim and Angel Carracedo: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006960    

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Heterogeneous recombination among Hepatitis B virus genotypes

Posted on September 22, 2017 by Miguel Arenas

A very interesting paper on heterogeneous recombination in Hepatitis B virus, just published in Infection, Genetics and Evolution http://www.sciencedirect.com/science/article/pii/S1567134817302721  

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