Jose Tubio’s research focuses on the impact of structural variation in cancer development, and the genetic changes that make cancers contagious between individuals.
The main focus of my research interests along my scientific career has been the impact of genomic structural variation (especially retrotransposition) on the function of eukaryotic genomes, and its role in disease (especially cancer). My research group is participating in the Pancancer Initiative of the International Cancer Genome Consortium (ICGC) and the Cancer Genome Atlas (TCGA), to investigate the mechanisms of coevolution between TEs and cancer. In addition, I am increasingly interested in the identification of drivers of cancer transmissibility in clonally transmissible cancers (i.e., cancers that are transmitted between individuals by direct transfer of living cancer cells).
Bernardo Rodríguez Martín, PhD student
Eva García Álvarez, PhD student
Alicia L. Bruzos, PhD student
Other lab members:
Pilar Alvariño, Lab technician
More at Researchgate
Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.
Tubio JM, Li Y, Ju YS, Martincorena I, Cooke SL et al.
Cancer: When catastrophe strikes a cell.
Tubio JM and Estivill X.
PUBMED: 21350479; DOI: doi:10.1038/470476a