Author Archives: dposada

New paper on germline evolution of human cancer genes by Alberto Vicens

https://www.mdpi.com/2073-4425/9/12/582

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Comparing single-cell whole-genome amplification strategies

We finally put it together: https://www.biorxiv.org/content/early/2018/10/16/443754

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Welcome to Monica and Fabian!

Monica Valecha (India) and Fabián Crespo (Cuba/Ecuador) just arrived to start as PhD students in the CONTRA Marie Curie Innovative Training Network on Computational Oncology.  They are going to work on different aspects of cancer evolution. Welcome to the lab!. Now … Continue reading

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Merly got her PhD

Congratulations to Merly for her PhD awarded today on NGS phylogenomics! You’ve been a GREAT student. Good luck for your postdoc at UC Santa Cruz. We’ll miss you…  

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NGS coverage and evolutionary inferences from single-cells

New paper just out @GenomeMedicine! We report the impact of sequencing depth (and sampling effort) towards variant detection, genotype accuracy, clonal inference and phylogenetic reconstruction from single-cell cancer data. https://rdcu.be/LJ4E

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Whole-genome assembly of the coral reef Pearlscale Pygmy Angelfish

Congratulations Iria for publishing a very nice paper describing the assembly of the genome of a beautiful angelfish! https://www.nature.com/articles/s41598-018-19430-x  

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Two open PhD positions in computational cancer evolution!

Two open Marie Curie PhD positions (CONTRA ITN)  in computational cancer evolution at our lab. Please apply!    ESR 11: Estimation of tumour growth rates from NGS data Understanding the process of tumour growth is fundamental for many aspects of cancer … Continue reading

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Jose Tubio moves to USC!

Jose Tubio is moving to the University of Santiago de Compostela with his team. Best wishes Jose!

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Eco-evo classification of tumors

Nice to contribute to this consensus statement in Nature Reviews Cancer about classifying tumors according to their ecological and evolutionary features: http://go.nature.com/2fopLbX   

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Multiregional tumor trees are not phylogenies

Our comment about misusing multiregional trees in cancer is out:   Alves JA, Prieto T, Posada D. 2017. Multiregional tumor trees are not phylogenies. Trends in Cancer: 0.1016/j.trecan.2017.06.004   https://t.co/HVb8dVpi6O   Here we show that multiregional tumor trees built from bulk … Continue reading

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