Monthly Archives: March 2018

NGSphy: phylogenomic simulation of next-generation sequencing data

NGSphy, our tool for simulating NGS reads along gene trees or genome-wide along a species tree with multiple gene families, is now published in Bioinformatics. https://academic.oup.com/bioinformatics/advance-article-abstract/doi/10.1093/bioinformatics/bty146/4925260?redirectedFrom=fulltext Source code, full documentation, and tutorials including a “Getting started” guide are available at http://github.com/merlyescalona/ngsphy

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Substitution Rates Predicted by Stability-Constrained Models of Protein Evolution Are Not Consistent with Empirical Data

Both stability-constrained and structure-constrained substitution models are required to realistically predict the effect of mutations during protein evolution. A great study with Ugo Bastolla’s lab just published in Molecular Biology and Evolution, https://academic.oup.com/mbe/article-abstract/35/3/743/4775142?redirectedFrom=fulltext

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